IIQ
Pablo Vázquez Domínguez, Antonio Romero Arenas, Rosario Fernández, José María Lassaletta, Abel Ros ACS Catalysis 2023, Vol. 13, 42-28
The catalytic hydroarylation of alkynes has emerged as an excellent methodology for the synthesis of functionalized alkenes with excellent levels of regio- and stereocontrol (syn). However, in spite of the great progress in this field, the number of asymmetric methodologies is still scarce. Herein, we report an atroposelective Ir-catalyzed C–H hydroarylation of alkynes, which enables the asymmetric synthesis of axially chiral heterobiaryl trisubstituted olefins in good to high yields and enantioselectivities up to 98% ee.
https://doi.org/10.1021/acscatal.2c04524
El investigador Pablo Vázquez Domínguez
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