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Paper of the month

Trehalose-based Siamese twin amphiphiles with tunable self- assembling, DNA nanocomplexing and gene delivery properties

IIQ

Ana I. Carbajo-Gordillo, Julio Rodríguez-Lavado, José L. Jiménez Blanco, Juan M. Benito, Christophe Di Giorgio, Itziar Vélaz, Concepción Tros de Ilarduya, Carmen Ortiz Mellet and José M. García Fernández. Chemical Communications 2019, Vol. 55, 8227-8230

An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo.

https://doi.org/10.1039/C9CC04489B

 

 

Ana Isabel Carbajo