cicCartuja Centro de Investigaciones Científicas de la cartuja

  • Jobs & Training>>
  • International Symposium Membrane-Less Organelles in Cell Life and Disease
< Alberto Jiménez Premio Extrardinario de Doctorado 2016-2017
18 October 2019 11:46 Age: 2 Years
Category: IIQ

International Symposium Membrane-Less Organelles in Cell Life and Disease

It will be held in Seville (Spain), on 10 - 11 March 2020, under the auspices of Ramón Areces Foundation at cicCartuja.

The International Symposium on Membrane-Less Organelles in Cell Life and Disease will be focused on the characterization of cellular organelles lacking membrane boundaries, as well as on their involvement in cell metabolism and disease progression. It will be held in Seville (Spain), on 10 - 11 March 2020, under the auspices of Ramón Areces Foundation at cicCartuja, a joint research center of the University of Seville (US), the Spanish Research Council (CSIC) and the Autonomous Government of Andalusia, and it will be coordinated by Professors at the University of Seville, Miguel A. De la Rosa and Irene Díaz-Moreno.

How do cells enable internal spatiotemporal control of complex biochemical reactions?

How do cells enable internal spatiotemporal control of complex biochemical reactions? They have partly solved this question by creating compartments, or organelles, that allow distinct chemical environments. Most of these compartments are surrounded by membranes (nucleus, mitochondria, chloroplasts, lisosomes, etc.). It is thus easy to understand how such membrane-bound compartments cohabit and work in the cells. On the contrary, many other compartments (nucleoli, centrosomes, Cajal bodies, stress granules, etc.) lack membranes and explaining their coexistence inside the cells is harder. Such membrane-less organelles (MLOs) remain separated in the cell by avoiding the mixture of their components with the surroundings. The following questions soon arise: Are there molecules transported in and out of MLOs? How fast must the diffusion of the components within MLOs be to guarantee efficient chemical reactions?

Recent experimental evidences have shown that many MLOs are liquid droplets formed by phase separation, thereby allowing MLO components to be rapidly concentrated in a concrete place in the cell. The transient assembly of liquid drops is driven by i) multivalent weak interactions between signaling domains repetitively included in proteins and RNA, and ii) substantial conformational heterogeneities of intrinsically disordered regions. Under cell pathology and devastating aggregation diseases, liquid-liquid demixing can eventually turn into metastable condensates of intracellular matter, such as glass/hydrogels or amyloid-like fibers, that undergo liquid-solid phase transitions.

Altogether, liquid-liquid phase separation provides a simple but smart mechanism for the cell to control the spatial localization and processing of molecules, without relying on membrane boundaries.

Cellular biology approaches combined with quantitative biophysical and structural tools are required to elucidate how such non-equilibrium events in living cells control intracellular phase behavior. In this Symposium, the confluence between physicists and cellular and molecular biologists will let us go deeply into the formation of MLOs by liquid-liquid phase transitions and the formation of drops (or droplets) inside the cell. This Symposium aims at gathering pioneering scientists in such a cutting-edge interdisciplinary topic to discuss on MLOs and their impact on diseases. Because of its relevance and novelty, the Symposium will host a round table with senior editors of the three top journals influencing science policy (Cell, Nature, Science).  

 


Center News

23 July 2018

Javier Ramos Soriano (IIQ), doble reconocimiento por su tesis doctoral

Premio Nacional mejor Tesis Doctoral 2017 sobre Carbohidratos y Premio Territorial mejores Tesis Doctorales curso 16-17 sobre Química.


20 July 2018

A. Guerra-Castellano (IIQ), premio mejores tesis doctorales curso 16-17

Los hallazgos descritos en su tesis proporcionan un nuevo marco para investigar la modulación de la actividad mitocondrial por fosforilación del citocromo c.


19 July 2018

El IIQ acerca la ciencia a los colegios de Sevilla

La comisión de divulgación agradece al personal técnico y científico las diversas actividades realizadas durante el curso escolar 2017-2018


18 July 2018

La lección del brócoli en la lucha contra el cáncer

Investigadores del IIQ y la US logran sintetizar compuestos con propiedades anticancerígenas mejorando las características del sulforafano


18 July 2018

Un estudio revela las bases de la respuesta mitocondrial ante la hipoxia

Investigadores del IIQ publican en PNAS las bases moleculares de la respuesta de las células cerebrales ante la falta de oxígeno


18 June 2018

Consolación Álvarez (IBVF), investigadora del programa ComFuturo

Esta colaboración público-privada financiará durante tres años su proyecto: Diseño de nuevos biofertilizantes de uso agrícola.


8 June 2018

Jornada de formación: Normalización de Autoría y Perfiles de Investigador

El 18 de junio en cicCartuja, jornada teórica y práctica sobre las herramientas de normalización de autoría y creación de perfiles de investigador.