cicCartuja Centro de Investigaciones Científicas de la cartuja

< Alberto Jiménez Premio Extrardinario de Doctorado 2016-2017
18 October 2019 11:46 Age: 5 Years
Category: IIQ

International Symposium Membrane-Less Organelles in Cell Life and Disease

It will be held in Seville (Spain), on 10 - 11 March 2020, under the auspices of Ramón Areces Foundation at cicCartuja.

The International Symposium on Membrane-Less Organelles in Cell Life and Disease will be focused on the characterization of cellular organelles lacking membrane boundaries, as well as on their involvement in cell metabolism and disease progression. It will be held in Seville (Spain), on 10 - 11 March 2020, under the auspices of Ramón Areces Foundation at cicCartuja, a joint research center of the University of Seville (US), the Spanish Research Council (CSIC) and the Autonomous Government of Andalusia, and it will be coordinated by Professors at the University of Seville, Miguel A. De la Rosa and Irene Díaz-Moreno.

How do cells enable internal spatiotemporal control of complex biochemical reactions?

How do cells enable internal spatiotemporal control of complex biochemical reactions? They have partly solved this question by creating compartments, or organelles, that allow distinct chemical environments. Most of these compartments are surrounded by membranes (nucleus, mitochondria, chloroplasts, lisosomes, etc.). It is thus easy to understand how such membrane-bound compartments cohabit and work in the cells. On the contrary, many other compartments (nucleoli, centrosomes, Cajal bodies, stress granules, etc.) lack membranes and explaining their coexistence inside the cells is harder. Such membrane-less organelles (MLOs) remain separated in the cell by avoiding the mixture of their components with the surroundings. The following questions soon arise: Are there molecules transported in and out of MLOs? How fast must the diffusion of the components within MLOs be to guarantee efficient chemical reactions?

Recent experimental evidences have shown that many MLOs are liquid droplets formed by phase separation, thereby allowing MLO components to be rapidly concentrated in a concrete place in the cell. The transient assembly of liquid drops is driven by i) multivalent weak interactions between signaling domains repetitively included in proteins and RNA, and ii) substantial conformational heterogeneities of intrinsically disordered regions. Under cell pathology and devastating aggregation diseases, liquid-liquid demixing can eventually turn into metastable condensates of intracellular matter, such as glass/hydrogels or amyloid-like fibers, that undergo liquid-solid phase transitions.

Altogether, liquid-liquid phase separation provides a simple but smart mechanism for the cell to control the spatial localization and processing of molecules, without relying on membrane boundaries.

Cellular biology approaches combined with quantitative biophysical and structural tools are required to elucidate how such non-equilibrium events in living cells control intracellular phase behavior. In this Symposium, the confluence between physicists and cellular and molecular biologists will let us go deeply into the formation of MLOs by liquid-liquid phase transitions and the formation of drops (or droplets) inside the cell. This Symposium aims at gathering pioneering scientists in such a cutting-edge interdisciplinary topic to discuss on MLOs and their impact on diseases. Because of its relevance and novelty, the Symposium will host a round table with senior editors of the three top journals influencing science policy (Cell, Nature, Science).  


Center News

18 March 2017

ICMS-sci-talks, charlas científicas impartidas por miembros del ICMS

La actividad pretende erigirse en un foro en el que exponer los resultados de sus publicaciones más recientes

17 March 2017

Miguel Anaya (ICMS), Premio Joven a la Cultura Científica 2016

El Consistorio reconoce su investigación en el diseño y fabricación de dispositivos optoelectrónicos basados en perovskitas.

24 February 2017

El jurado de la séptima edición se reúne para elegir a los ganadores

El acto público de entrega del “Premio cicCartuja Ebro Foods” tendrá lugar el viernes 28 de abril de 2017

24 February 2017

Jesús Campos (IIQ), Premio Real Maestranza de Caballería 2016

Sus estudios se centran en procesos catalíticos para síntesis orgánica y aplicaciones en química verde o sostenible

23 February 2017

cicCartuja acoge un taller para la preparación de propuestas del ERC

El taller se celebra el 2 de marzo y está orientado a las convocatorias Advanced 2017 y futuras convocatorias de 2018

13 February 2017

Arranca la primera edición de ‘cicCartuja PhD Talks’

Esta iniciativa, promovida por estudiantes de Doctorado del centro, establecerá lazos de colaboración entre investigadores y enriquecerá su formación.

6 February 2017

Bancos de helio sólido para experimentos de Física Nuclear

Científicos del ICMS fabrican un material a base de silicio y helio que resulta estable durante años e inalterable a altas temperaturas