cicCartuja Centro de Investigaciones Científicas de la cartuja

< Alberto Jiménez Premio Extrardinario de Doctorado 2016-2017
18 October 2019 11:46 Age: 3 Years
Category: IIQ

International Symposium Membrane-Less Organelles in Cell Life and Disease

It will be held in Seville (Spain), on 10 - 11 March 2020, under the auspices of Ramón Areces Foundation at cicCartuja.

The International Symposium on Membrane-Less Organelles in Cell Life and Disease will be focused on the characterization of cellular organelles lacking membrane boundaries, as well as on their involvement in cell metabolism and disease progression. It will be held in Seville (Spain), on 10 - 11 March 2020, under the auspices of Ramón Areces Foundation at cicCartuja, a joint research center of the University of Seville (US), the Spanish Research Council (CSIC) and the Autonomous Government of Andalusia, and it will be coordinated by Professors at the University of Seville, Miguel A. De la Rosa and Irene Díaz-Moreno.

How do cells enable internal spatiotemporal control of complex biochemical reactions?

How do cells enable internal spatiotemporal control of complex biochemical reactions? They have partly solved this question by creating compartments, or organelles, that allow distinct chemical environments. Most of these compartments are surrounded by membranes (nucleus, mitochondria, chloroplasts, lisosomes, etc.). It is thus easy to understand how such membrane-bound compartments cohabit and work in the cells. On the contrary, many other compartments (nucleoli, centrosomes, Cajal bodies, stress granules, etc.) lack membranes and explaining their coexistence inside the cells is harder. Such membrane-less organelles (MLOs) remain separated in the cell by avoiding the mixture of their components with the surroundings. The following questions soon arise: Are there molecules transported in and out of MLOs? How fast must the diffusion of the components within MLOs be to guarantee efficient chemical reactions?

Recent experimental evidences have shown that many MLOs are liquid droplets formed by phase separation, thereby allowing MLO components to be rapidly concentrated in a concrete place in the cell. The transient assembly of liquid drops is driven by i) multivalent weak interactions between signaling domains repetitively included in proteins and RNA, and ii) substantial conformational heterogeneities of intrinsically disordered regions. Under cell pathology and devastating aggregation diseases, liquid-liquid demixing can eventually turn into metastable condensates of intracellular matter, such as glass/hydrogels or amyloid-like fibers, that undergo liquid-solid phase transitions.

Altogether, liquid-liquid phase separation provides a simple but smart mechanism for the cell to control the spatial localization and processing of molecules, without relying on membrane boundaries.

Cellular biology approaches combined with quantitative biophysical and structural tools are required to elucidate how such non-equilibrium events in living cells control intracellular phase behavior. In this Symposium, the confluence between physicists and cellular and molecular biologists will let us go deeply into the formation of MLOs by liquid-liquid phase transitions and the formation of drops (or droplets) inside the cell. This Symposium aims at gathering pioneering scientists in such a cutting-edge interdisciplinary topic to discuss on MLOs and their impact on diseases. Because of its relevance and novelty, the Symposium will host a round table with senior editors of the three top journals influencing science policy (Cell, Nature, Science).  

 


Center News

25 April 2022

Tomás Ramírez Reina premiado por su labor científica internacional

El investigador del ICMS es galardonado con el Premio a la Trayectoria Científica de Excelencia FISOCAT 2022 Junior.

Category: cicCartuja

22 April 2022

Vuelve el concurso de nanorelatos del Festival de 10alamenos9

Se abre el plazo para la presentación de solicitudes hasta el 18 de mayo de 2022.

Category: cicCartuja

23 February 2022

Alberto Palmero organiza un simposio sobre Ciencia y Tecnología en el CNMAT

El investigador del ICMS, organiza junto con dos investigadores más, un Simposio dentro del XVI Congreso Nacional de Materiales


21 February 2022

Ya se conocen los ganadores del premio cicCartuja Ebro Foods en su 12ª edición

Xabier García Casas del Instituto de Ciencia de Materiales de Sevilla (ICMS) ha conseguido el primer premio.

Category: cicCartuja

10 February 2022

Arranca la VII del 11F, el Día de la Mujer y la Niña en la Ciencia

El 11 de febrero nos volvemos a sumar a esta iniciativa para eliminar los estereotipos de género en STEM.

Category: cicCartuja

29 November 2021

Jesús Campos, condecorado por la Academia Joven de España

La AJE celebró, por primera vez desde su creación, el acto de Imposición de Medallas a los nuevos Académicos de Número, donde el investigador del IIQ recibió también la suya.

Category: IIQ

23 November 2021

Ana Borrás gana el Premio Losada Villasante

La investigadora del ICMS y jefa del Grupo de Nanotecnología en Superficies y Plasma, obtiene este reconocimiento a la Investigación en Innovación por su trabajo "Análisis sobre materiales avanzados para la captación de energía...

Category: ICMS