IIQ
Patricia Rodríguez Salamanca, Rocío Martín de la Calle, Verónica Rodríguez, Pedro Merino, Rosario Fernández, José M. Lassaletta and Valentín Hornillos. Chemical Science 2021, Vol. 12, 15291-15297
A copper-catalyzed asymmetric intramolecular reductive cyclization for the synthesis of dibenzo[b,d]azepines is described. Use of 2′-vinyl-biaryl-2-imines as substrates and in situ formed [CuI/(Ph-BPE)] as the catalyst enables the synthesis of 7-membered bridged biarylamines containing both central and axial stereogenic elements in high yields (up to 98%) and with excellent diastereo- and enantioselectivities (>20 : 1 d.r., up to 99% ee). Moreover, the same catalyst was found to facilitate a related borylative cyclization to afford versatile boronic ester derivatives. Both reactions proceed under mild conditions (rt) and are applicable to a variety of substituted aromatic and heterocyclic derivatives.
Patricia Rodríguez
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