[60]Fullerene as Multivalent Scaffold: Efficient Molecular Recognition of Globular Glycofullerenes by Concanavalin A

Jun 27, 2011 | Artículos del Mes

A carbohydrate–protein interaction is a key step in many biological processes. This recognition event is, in several cases, one of the first selective steps that triggers a series of biological processes leading to biological functions. This interaction is...

Symmetry Complementarity‐Guided Design of Anthrax Toxin Inhibitors Based on β‐Cyclodextrin: Synthesis and Relative Activities of Face‐Selective Functionalized Polycationic Clusters

May 27, 2011 | Artículos del Mes, Artículos del Mes, Artículos del Mes, Artículos del Mes, Artículos del Mes

En este trabajo se describe el desarrollo de tres nuevas series de inhibidores potenciales de la toxina del Ántrax basados en la plataforma de la β‐ciclodextrina (βCD). El diseño se basa en el concepto de la ‘complementariedad de simetría’ entre derivados...

Structure and support induced structure disruption of soft nanoparticles obtained from hydroxylated fatty acids

Abr 27, 2011 | 2011, 2011, 2011, 2011, 2011, 2011

Soft and spherical nanoparticles, named as cutinsomes, have been prepared from concentrated 9(10),16-dihydroxypalmitic acid (diHPA) in aqueous solution. After isolation, cutinsomes have been chemically and structurally characterized by ATR-FTIR, TEM and dynamic atomic...

Copper-Catalyzed Azide–Alkyne Cycloaddition in the Synthesis of Polydiacetylene: «Click Glycoliposome» as Biosensors for the Specific Detection of Lectins

Mar 27, 2011 | Sin categoría

Supramolecular self-assembly of conjugated diacetylenic amphiphile-tethered ligands photopolymerize to afford polydiacetylene (PDA) functional liposomes. Upon specific interaction with a variety of biological analytes in aqueous solution, PDA exhibits rapid...

Inhibition of Arabidopsis O-Acetylserine(thiol)lyase A1 by Tyrosine-Nitration

Feb 27, 2011 | Sin categoría

The last step of sulfur assimilation is catalyzed by O‐acetylserine(thiol)lyase (OASTL) enzymes. OASTLs are encoded by a multigene family in the model plant Arabidopsis thaliana. Cytosolic OASA1 enzyme is the main source of OASTL activity and thus crucial for cysteine...

Gold supported on metal-doped ceria catalysts (M=Zr, Zn and Fe) for the preferential oxidation of CO (PROX)

Ene 27, 2011 | Sin categoría

A series of ceria oxides doped with 10 mol.% of Zr, Zn and Fe has been prepared by a pseudo sol‐gel method throughout the thermal decomposition of the corresponding metallic propionates. With these supports, 1 wt.% gold catalysts were prepared by the deposition-...