Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection
Ligand polyvalency is a powerful modulator of protein–receptor interactions. In particular, host–pathogen infection interactions are often mediated by glycan ligand–protein interactions. The study of these interactions using synthetic compounds with very high copy...
Characterization of a Paramagnetic, Mononuclear Pt (II)-Alkyl Complex Intermediate in Carbon-Halogen Bond Coupling Reaction
Addition of Br2 or I2 to 14-electron, cationic Pt(II)-alkyl complexes led to the formation of the corresponding carbon-halogen Pt(II) coupling products. Low temperature experiments with Br2 allowed us to isolate and characterize crystallographically a very unusual...
Tuning N-Heterocyclic Carbenes in T-Shaped PtII Complexes for Intermolecular CH Bon Activation of Arenes
En portadaTuning N-Heterocyclic Carbenes in T-Shaped PtII Complexes for Intermolecular CH Bon Activation of Arenes La transformación de sustancias químicas simples en otras más complejas (denominado como “funcionalización”) está entre los objetivos primordiales de los...
Characterization of the kisspeptin system in human spermatozoa
Kisspeptin, the product of the KISS1 gene, plays an essential role in the regulation of spermatogenesis acting primarily at the hypothalamic level of the gonadotropic axis. However, the presence of kisspeptin and its canonical receptor, KISS1R, in spermatozoa has not...