Copper-Catalyzed Azide–Alkyne Cycloaddition in the Synthesis of Polydiacetylene: «Click Glycoliposome» as Biosensors for the Specific Detection of Lectins
Supramolecular self-assembly of conjugated diacetylenic amphiphile-tethered ligands photopolymerize to afford polydiacetylene (PDA) functional liposomes. Upon specific interaction with a variety of biological analytes in aqueous solution, PDA exhibits rapid...
Polycationic Amphiphilic Cyclodextrins for Gene Delivery: Synthesis and Effect of Structural Modifications on Plasmid DNA Complex Stability, Cytotoxicity, and Gene Expression
A molecular-diversity-oriented approach for the preparation of well-defined polycationic amphiphilic cyclodextrins paCDs) as gene-delivery systems is reported. The synthetic strategy takes advantage of the differential reactivity of primary versus secondary hydroxyl...
Improved non-covalent biofunctionalization of Multi-Walled Carbon Nanotubes using Carbohydrates Amphiphiles with a Butterfly-Like Polyaromatic tail
We have developed an efficient strategy for the non-covalent functionalization of multi-wall carbon nanotubes (MWCNTs) which allows a biomimetic presentation of carbohydrates on their surface by π-π stacking interactions. The strategy is based on the use of...
Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation
Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure and function. Human cytochrome c, with five tyrosine residues, is an excellent case study as it is a well-known protein playing a double...