Reversible Bimetallic Inhibition to Modulate Selectivity During Catalysis
Bimetallic complexes have demonstrated a great ability to enhance the activity of monometallic systems for bond activation and catalysis. In this work, we explore the opposite approach: using a second metal to passivate the activity of another by reversible bimetallic...
Jesús Campos del IIQ y Tomás Ramírez del ICMS obtienen las ayudas Consolidator Grants del ERC
Jesús Campos del IIQ y Tomás Ramírez del ICMS reciben las ayudas Consolidator Grants del European Research Council, dotadas con dos millones de euros durante cinco años para cada proyecto. Dos proyectos de investigación del cicCartuja han obtenido las ayudas...
Catalytic Atroposelective Synthesis of C−N Axially Chiral Aminophosphines via Dynamic Kinetic Resolution
A ruthenium-catalyzed reductive amination via asymmetric transfer hydrogenation (ATH) has been used to perform an efficient dynamic kinetic resolution (DKR) of N-aryl 2-formyl pyrroles decorated with a phosphine moiety positioned at the ortho’ position. The strategy...
Phosphorylation at the disordered N-end makes HuR accumulate and dimerize in the cytoplasm
Human antigen R (HuR) is an RNA binding protein mainly involved in maintaining the stability and controlling the translation of mRNAs, critical for immune response, cell survival, proliferation and apoptosis. Although HuR is a nuclear protein, its mRNA...