Dynamic Kinetic Resolution of Indole-Based Sulfenylated Heterobiaryls by Rhodium-Catalyzed Atroposelective Reductive Aldol Reaction
A highly enantio- and diastereoselective dynamic kinetic resolution (DKR) of configurationally labile 3-aryl indole-2-carbaldehydes is described. The DKR proceeds via a Rh-catalyzed intermolecular asymmetric reductive aldol reaction with acrylate esters, with...
Fluorinated Man9 as a high mannose mimetic to unravel its recognition by DC-SIGN using NMR
Lectins are capable of reading out the structural information contained in carbohydrates through specific recognition processes. Determining the binding epitope of the sugar is fundamental to understanding this recognition event. Nuclear magnetic resonance (NMR) is a...
Imaging Saturation Transfer Difference (STD) NMR: affinity and specificity of protein-ligand interactions from a single NMR sample
En portadaImaging Saturation Transfer Difference (STD) NMR: affinity and specificity of protein-ligand interactions from a single NMR sample Las investigaciones sobre la naturaleza física y química de los procesos de reconocimiento molecular entre biomoléculas nos...
Dynamic Kinetic Resolution of 2-(Quinolin-8-yl)benzaldehydes: Atroposelective Iridium-Catalyzed Transfer Hydrogenative Allylation
An atroposelective Ir-catalyzed dynamic kinetic resolution (DKR) of 2-(quinolin-8-yl)benzaldehydes/1-naphthaldehydes by transfer hydrogenative coupling of allyl acetate is disclosed. The allylation reaction takes place with simultaneous installation of central and...