Glycodendrimers as chondroitin sulfate mimetics: synthesis and binding to growth factor midkine
Chondroitin sulfate (CS) is a member of the glycosaminoglycan (GAG) family, a class of polysaccharides implicated in relevant biological functions. The structural complexity of these carbohydrates demands the development of simple glycomimetics as useful tools to...
Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48
Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its dysfunction can lead to hypoxia-dependent pathologies such as ischemia and cancer. Although cytochrome c phosphorylation—in particular, at...
A Cationic Unsaturated Platinum(II) Complex that Promotes the Tautomeration of Acetylene to Vinylidene
Complex [PtMe2 (PMe2 ArDipp2)] (1), which contains a tethered terphenyl phosphine (ArDipp2 =2,6-(2,6-(i) Pr2 C6 H3)2 C6 H3), reacts with [H(Et2 O)2 ]BArF (BArF(-) =B[3,5-(CF3 )2 C6 H3 ]4(-) ) to give the solvent (S) complex [PtMe(S)(PMe2 ArDipp2)](+) (2⋅S). Although...
Probing Conformational Exchange Dynamics in a Short-Lived Protein Folding Intermediate by Real-Time Relaxation–Dispersion NMR
En portadaProbing Conformational Exchange Dynamics in a Short-Lived Protein Folding Intermediate by Real-Time Relaxation–Dispersion NMR El término amiloidosis hace referencia a un grupo de enfermedades raras y degenerativas, como el alzheimer, el parkinson, algunos...