Organocatalytic Asymmetric Cyanosilylation of Nitroalkenes
A new catalyst type for a new reaction. The unprecedented cyanosilylation of nitroalkenes can be efficiently catalyzed by a bifunctional quinine derivative bearing tetra-alkylammonium cyanide and thiourea moieties. The activation of the nitroalkene by H-bonding to the...
Ligand-Receptor Binding Affinities from Saturation Transfer Difference (STD) NMR Spectroscopy: The Binding Isotherm of STD Initial Growth Rates
En portadaLigand-Receptor Binding Affinities from Saturation Transfer Difference (STD) NMR Spectroscopy: The Binding Isotherm of STD Initial Growth Rates The direct evaluation of dissociation constants (KD) from the variation of saturation transfer difference (STD)...
Insights in cellular uptake mechanisms of pDNA–polycationic amphiphilic cyclodextrin nanoparticles (CDplexes)
En portadaInsights in cellular uptake mechanisms of pDNA–polycationic amphiphilic cyclodextrin nanoparticles (CDplexes) It is generally recognized that the major obstacle to afford an efficient gene delivery is cellular internalization and endosomal escape of the DNA....
Cyclometallation and Hydrogen/Deuterium Exchange Reactions of an Arylphosphine Ligand upon Coordination to {Ir(C5Me5)}
The cyclometallated compounds [(C5Me5)Ir(X){PMe(2,6-CH2(Me)C6H3)(2,6-Me2C6H3)}] (X=Cl, H, Me) have been synthesized in high yields and their potential for C-H activation demonstrated. Subsequent functionalization of these species has provided a series of complexes...