Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
Fully homogeneous facial amphiphiles consisting in a cyclodextrin(CD) platform onto which a polycationic cluster and a multi-tail hydrophobic moiety have been installed (polycationic amphiphilic CDs; paCDs) self-organized in the presence of plasmid DNA to form...![[60]Fullerene as Multivalent Scaffold: Efficient Molecular Recognition of Globular Glycofullerenes by Concanavalin A](https://www.ciccartuja.es/wp-content/uploads/sites/4/2024/11/ChemEurJ2011.gif)
[60]Fullerene as Multivalent Scaffold: Efficient Molecular Recognition of Globular Glycofullerenes by Concanavalin A
A carbohydrate–protein interaction is a key step in many biological processes. This recognition event is, in several cases, one of the first selective steps that triggers a series of biological processes leading to biological functions. This interaction is...
Symmetry Complementarity‐Guided Design of Anthrax Toxin Inhibitors Based on β‐Cyclodextrin: Synthesis and Relative Activities of Face‐Selective Functionalized Polycationic Clusters
En este trabajo se describe el desarrollo de tres nuevas series de inhibidores potenciales de la toxina del Ántrax basados en la plataforma de la β‐ciclodextrina (βCD). El diseño se basa en el concepto de la ‘complementariedad de simetría’ entre derivados...
Structure and support induced structure disruption of soft nanoparticles obtained from hydroxylated fatty acids
Soft and spherical nanoparticles, named as cutinsomes, have been prepared from concentrated 9(10),16-dihydroxypalmitic acid (diHPA) in aqueous solution. After isolation, cutinsomes have been chemically and structurally characterized by ATR-FTIR, TEM and dynamic atomic...