Symmetry Complementarity‐Guided Design of Anthrax Toxin Inhibitors Based on β‐Cyclodextrin: Synthesis and Relative Activities of Face‐Selective Functionalized Polycationic Clusters
En este trabajo se describe el desarrollo de tres nuevas series de inhibidores potenciales de la toxina del Ántrax basados en la plataforma de la β‐ciclodextrina (βCD). El diseño se basa en el concepto de la ‘complementariedad de simetría’ entre derivados...
Structure and support induced structure disruption of soft nanoparticles obtained from hydroxylated fatty acids
Soft and spherical nanoparticles, named as cutinsomes, have been prepared from concentrated 9(10),16-dihydroxypalmitic acid (diHPA) in aqueous solution. After isolation, cutinsomes have been chemically and structurally characterized by ATR-FTIR, TEM and dynamic atomic...
Copper-Catalyzed Azide–Alkyne Cycloaddition in the Synthesis of Polydiacetylene: “Click Glycoliposome” as Biosensors for the Specific Detection of Lectins
Supramolecular self-assembly of conjugated diacetylenic amphiphile-tethered ligands photopolymerize to afford polydiacetylene (PDA) functional liposomes. Upon specific interaction with a variety of biological analytes in aqueous solution, PDA exhibits rapid...
Inhibition of Arabidopsis O-Acetylserine(thiol)lyase A1 by Tyrosine-Nitration
The last step of sulfur assimilation is catalyzed by O‐acetylserine(thiol)lyase (OASTL) enzymes. OASTLs are encoded by a multigene family in the model plant Arabidopsis thaliana. Cytosolic OASA1 enzyme is the main source of OASTL activity and thus crucial for cysteine...


