Broad Scope Synthesis of Ester Precursors of Nonfunctionalized Chiral Alcohols Based on the Asymmetric Hydrogenation of α,β- Dialkyl-, α,β- Diaryl-, and α-Alkyl-β-aryl-vinyl Esters
The catalytic asymmetric hydrogenation of trisubstituted enol esters using Rh catalysts bearing chiral phosphinephosphite ligands (P-OP) has been studied. Substrates covered comprise α,β-dialkyl, α-alkyl-β-aryl, and α,β-diarylvinyl esters, the corresponding...
Glycodendrimers as chondroitin sulfate mimetics: synthesis and binding to growth factor midkine
Chondroitin sulfate (CS) is a member of the glycosaminoglycan (GAG) family, a class of polysaccharides implicated in relevant biological functions. The structural complexity of these carbohydrates demands the development of simple glycomimetics as useful tools to...
Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48
Regulation of mitochondrial activity allows cells to adapt to changing conditions and to control oxidative stress, and its dysfunction can lead to hypoxia-dependent pathologies such as ischemia and cancer. Although cytochrome c phosphorylation—in particular, at...
A Cationic Unsaturated Platinum(II) Complex that Promotes the Tautomeration of Acetylene to Vinylidene
Complex [PtMe2 (PMe2 ArDipp2)] (1), which contains a tethered terphenyl phosphine (ArDipp2 =2,6-(2,6-(i) Pr2 C6 H3)2 C6 H3), reacts with [H(Et2 O)2 ]BArF (BArF(-) =B[3,5-(CF3 )2 C6 H3 ]4(-) ) to give the solvent (S) complex [PtMe(S)(PMe2 ArDipp2)](+) (2⋅S). Although...