“On Water” Nucleophilic Addition of Formaldehyde N,N-Dialkylhydrazones to α-Keto Esters
Water solves the problem: The use of pure water as the reaction mixture is key for the nucleophilic addition of formaldehyde hydrazones to α-keto esters, leading to highly functionalized carbinols in high yields and short reaction times. The need for heterogeneous...
Chemical Reactivity and Electrochemistry of Metal–Metal-Bonded Zincocenes
Attempts to prepare mixed-ligand zinc–zinc-bonded compounds that contain bulky C5Me5 and terphenyl groups, [Zn2(C5Me5)(Ar′)], lead to disproportionation. The resulting half-sandwich Zn(II) complexes [(η5-C5Me5)ZnAr′] (Ar′ = 2,6-(2,6-iPr2C6H3)2-C6H3, 2;...
Highly Enantioselective Hydrogenation of b-Acyloxy and b-Acylamino a,b-Unsaturated Phosphonates Catalyzed by Rhodium Phosphane-Phosphite Complexes
The enantioselective hydrogenation of b-(acyloxy)- and b-(acylamino)vinylphosphonates with rhodium catalysts based on chiral phosphane-phosphite ligands has been studied. In the case of the b-(acyloxy)vinylphosphonates, the reaction also produces an achiral...
Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
Fully homogeneous facial amphiphiles consisting in a cyclodextrin(CD) platform onto which a polycationic cluster and a multi-tail hydrophobic moiety have been installed (polycationic amphiphilic CDs; paCDs) self-organized in the presence of plasmid DNA to form...